Mathematical Modelling in Life Sciences

# course: PDEs in the neuroscience

speaker: Benoit Perthame (Université Pierre et Marie Curie, Paris)

abstract:
Neurons exchange informations via discharges, propagated by membrane potential, which trigger firing of the many connected neurons. How to describe large networks of such neurons? What are the properties of these mean-field equations? How can such a network generate a spontaneous activity?
Such questions can be tackled using nonlinear integro-differential equations.
These are now classically used in the neuroscience community to describe neuronal networks or neural assemblies. Among them, the best known is certainly Wilson-Cowan's equation which describe spiking rates arising in different brain locations.
Another classical model is the integrate-and-fire equation that describes neurons through their voltage using a particular type of Fokker-Planck equations. Several mathematical results will be presented concerning existence, blow-up, convergence to steady state, for the excitatory and inhibitory neurons, with or without refractory states. Conditions for the transition to spontaneous activity (periodic solutions) will be discussed.
One can also describe directly the spike time distribution which seems to encode more directly the neuronal information.
This leads to a structured population equation that describes at time $t$ the probability to find a neuron with time $s$ elapsed since its last discharge.
Here, we can show that small or large connectivity leads to desynchronization. For intermediate regimes, sustained periodic activity occurs.
A common mathematical tool is the use of the relative entropy method.
1. The single neuron, slow-fast dynamics,
2. The Integrate-and-Fire model, role of noise
3. Analysis of I&F model
4. Time elapsed models

timetable:
Wed 13 Sep, 11:00 - 12:30, Aula Dini
Thu 14 Sep, 9:00 - 10:30, Aula Magna Dipartimento di Matematica
Thu 14 Sep, 16:00 - 17:30, Aula Magna Dipartimento di Matematica
Fri 15 Sep, 11:00 - 12:30, Aula Magna Dipartimento di Matematica
documents:

NeuroCourse1

NeuroCourse2

NeuroCourse3

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