course: Extreme statistics of fast calcium transients in dendritic spines containing spine apparatus
speaker: Kanishka Basnayake (Ecole Normale Supérieure, Paris)abstract: When calcium is uncaged in the heads of dendritic spines containing a spine apparatus, transient calcium concentrations in the bases of the spines are determined by calcium induced calcium release from Ryanodine receptors. By combining biophysical modeling and analysis of calcium uncaging experiments, we show that the timescales triggering such calcium releases are determined by the extreme statistics of the first few ions that diffuse to the Ryanodine receptors. Using our computational model, we also predicted the distributions of Ryanodine receptors and SERCA pumps that we later confirmed experimentally. We conclude that calcium transients in spines with spine apparatus is a transduction mechanism where the activation timescale is governed by the asymmetrical distribution of receptors and the extreme statistics of the stochastic diffusion process.
timetable:
Thu 11 Oct, 12:00 - 13:00, Aula Dini
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