abstract: I will present a generalization of Mazur's conjectures to the non self-dual setting, especially to Rankin-Selberg L-functions of two GL2 forms with one cyclotomic variable (which via Iwasawa main conjectures applies to bounding Mordell-Weil rank in abelian towers of imaginary quadratic fields). In particular, I will present an asymptotic proof of this conjecture that uses only the existence of some associated p-adic L-function(s). If time permits, then I will also explain some open questions and directions for future research.