Nanoscale mathematical modeling of synaptic transmission, calcium dynamics, transduction and cell sensing
8 October 2018 - 12 October 2018This event is part of an intensive research period:
Advanced asymptotics of PDEs, modeling and extreme statistics and their applications to data analysis in cell biology.
Aims
Advances in high-precision sensing and imaging have emphasised the spatio-temporal nature of information transfer through signal transduction pathways. The compartmentalisation of signalling molecules and the existence of micro-domains are now widely acknowledged as key features in cell signalling. To complement experimental observations of spatio-temporal dynamics, mathematical modelling and analysis have emerged as a powerful tool. Using modelling, one can not only recapitulate experimentally observed dynamics of signalling molecules, but also gain an understanding of the underlying mechanisms in order to generate experimentally testable predictions.
We aim to provide introductory tutorials and discuss the application of mathematical modelling and analysis to the spatio-temporal dynamics of signalling pathways.